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Welcome to the draft “Patient-Centered Core Impact Sets (PC-CIS) Blueprint.” The National Health Council (NHC) aspires to ensure patient centricity in our health care ecosystem by advancing the Development of Patient-Centered Core Impact Sets (PC-CIS) to address inconsistencies between what is important to patients versus the information that is typically collected in research and care. A PC-CIS is a standardized, patient-derived and patient-prioritized list of the most important impacts a disease and/or its treatments have on a patient’s health and daily life, and that of their family and caregivers.