Prioritization Considerations and Methods

When the initial collection of patient-reported impacts happens, the breadth of what is reported will need to be prioritized to those impacts MOST important to patients before moving on to gathering data from other stakeholders. There are numerous methods that can be used in the prioritization process, and your research or methods partner(s) will likely have a preferred approach for such work.

Importantly, as Patient-Centered Core Impact Sets (PC-CIS) are an emerging and evolving tool, there is no proposed goal for the “ideal” number of prioritized impacts to arrive at. The expectation is that the correct number of impacts will vary by condition or population. In the development of the PC-CIS, the goal should be to compile the number of impacts representative of the full body of issues most important to patients and families. There is no gold-standard number.

Potential methods, examples, and guidances for prioritization include:

Delphi Method (panels and/or surveys)

Stated Preference Methods

Nominal Group Technique

  • Arthritis Foundation Live Yes! INSIGHTS Methodology Description

Discrete Choice Analysis

Mixed Methods

  • Patient-Important Outcomes in the Long-Term Treatment of Bipolar Disorder Case Example
  • PFMD Book of Good Practices and Patient Engagement Landscape paper (page 7)
  • The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) Handbook Chapter 3
  • The Core Outcome Set-STAdards for Development (COS-STAD) Guidelines for Core Outcome Set (COS) Development
  • Innovative Medicines Initiative (IMI), Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) Patient Preference Methodology

Arthritis Use Case

Arthritis Foundation, Prioritization by Patients